一、团队名称

畜禽替抗饲料添加剂研发及抗病营养关键调控创新团队

二、团队负责人

张海文，海南省高层次人才，海南省科协青年托举人才，海南省三区科技人才，省级科技特派员。主要研究方向为天然饲用抗生素替代品及功能性饲料添加剂。先后主持国家自然科学基金项目、海南省高层次人才项目、海南省科协青年创新人才项目等各级项目7项。出版专（编）著1部，参编书籍3部，发表学术论文60余篇，部分研究成果发表在《International Journal of Biological Macromolecules》《Poultry Science》《Food Research International》《Journal of Immunology》《Phytomedicine》《Journal of Agricultural and Food Chemistry》《Food & Function》《Molecular Pharmaceutics》《International Immunopharmacology》《Frontiers in Microbiology》《Animals》《Veterinary Immunology and Immunopathology》《Peptides》《Scientific Reports》等国际期刊。获得VKGAME威客电竞优秀班主任，优秀学业导师，优秀本科毕业论文指导教师称号，获得三区科技人才基层服务工作年度考核优秀评价。在第十九届“挑战杯”全国老员工课外学术科技作品竞赛2025年度中国青年科技创新“揭榜挂帅”擂台赛，荣获特等奖，指导员工在第五届中国“互联网+”老员工创新创业大赛海南赛区竞赛中荣获“青年红色筑梦之旅”赛道铜奖。

三、团队研究方向

1. 具有替代抗生素功能的畜禽饲料添加剂研发；

2. 通过营养手段调控畜禽肠道先天免疫功能；

3. 植物天然活性成分提取工艺研究与构效分析。

四、团队成员

石惠宇，博士，副教授

谭振，博士，讲师

五、团队代表性成果

1. 张海文, 管庆丰著,《动物营养与免疫概论》, 中国农业科学出版社, 2018, ISBN: 9787511635983.

2. Qin Xinyun^#; Nong Keyi^#; Liu Zhineng; Fang Xin; Zhang Bin; Chen Wanyan; Wang Zihan; Wu Yijia; Shi Huiyu; Wang Xuemei; Zhang Haiwen^*; Regulation of the intestinal flora using polysaccharides from Callicarpa nudiflora Hook to alleviate ulcerative colitis and the molecular mechanisms involved, International Journal of Biological Macromolecules, 2023, 258(Pt 1): 128887.（中科院1区，TOP期刊）

3. Fang Xin; Nong Keyi; Qin Xinyun; Liu Zhineng; Gao Feng; Jing Yuanli; Fan Haokai; Wang Zihan; Wang Xuemei; Zhang Haiwen^*; Effect of purple sweet potato-derived anthocyanins on heat stress response in Wenchang chickens and preliminary mechanism study, Poultry Science, 2023, 102(9): 102861. （中科院1区，TOP期刊）

4. Nong Keyi; Qin Xinyun; Liu Zhineng; Wang Zihan; Wu Yijia; Zhang Bin; Chen Wanyan; Fang Xin; Liu Youming; Wang Xuemei; Zhang Haiwen^*; Potential effects and mechanism of flavonoids extract of Callicarpa nudiflora Hook on DSS-induced colitis in mice, Phytomedicine, 2024, 128(3): 155523. （中科院1区，TOP期刊）

5. Liu Zhineng^#; Qin Xinyun^#; Nong Keyi; Fang Xin; Zhang Bin; Chen Wanyan; Wang Zihan; Wu Yijia; Shi Huiyu; Wang Xuemei; Zhang Haiwen^*; Oral administration of LfcinB alleviates DSS-induced colitis by improving the intestinal barrier and microbiota, Food & Function, 2024, 15(4): 2038 – 2051.（中科院1区，TOP期刊）

6. Nong Keyi^#; Liu Zhineng^#; Qin Xinyun; Chen Wanyan; Zhang Bin; Wu Yijia; Wang Zihan; Fang Xin; Liu Youming; Wang Xuemei; Sh Huiyui; Zhang Haiwen^*; Effect of the Pseudopleuronectes americanus-derived Pleurocidin on DSS-induced Ulcerative colitis in mice and its preliminary molecular mechanisms, International Immunopharmacology, 2024, 130: 111757. （中科院2区，TOP期刊）

7. Chen Tao; Hu Shihui; Zhang Haiwen^*; Guan Qingfeng; Yang Yuhui; Wang Xuemei^*; Anti-inflammatory effects of Dioscorea alata L. anthocyanins in a TNBS-induced colitis model, Food & Function, 2017, 8(2): 659-669.（中科院1区，TOP期刊）

8. Zhang Haiwen^*; Hua Rui; Zhang Bingxi; Guan Qingfeng; Zeng Jifeng; Wang Xuemei; Wang Beibei; Oral administration of bovine lactoferrin derived Lactoferricin (Lfcin) B could attenuate enterohemorrhagic Escherichia coli O157:H7 induced intestinal disease through improving intestinal barrier function and microbiota, Journal of Agricultural and Food Chemistry, 2019, 67(14): 3932-3945.（中科院1区，TOP期刊）

9. Qin Xinyun; Liu Zhineng; Nong Keyi; Fang Xin; Chen Wanyan; Zhang Bin; Wu Yijia; Wang Zihan; Shi Huiyu; Wang Xuemei; Zhang Haiwen^*; Porcine-derived antimicrobial peptide PR39 alleviates DSS-induced colitis via the NF-kappaB/MAPK pathway, International Immunopharmacology, 2024, 127: 111385. （中科院2区，TOP期刊）

六、团队合影